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Scyld ClusterWare, Adaptive Computing's Moab HPC Suite Power Leading Edge Research

Advanced cluster and workload management capabilities allow for optimized throughput and fair resource sharing for genomic sequencing jobs

FREMONT, Calif., and PROVO, Utah, Nov. 14 — Penguin Computing, a leading provider of HPC cluster solutions and Adaptive Computing, managers of the world's largest supercomputing systems as experts in HPC workload management, announced today that The Jackson Laboratory has chosen Scyld ClusterWare and Moab HPC Suite to process its genomic sequencing data.

Computational capabilities drive the two key areas of research at The Jackson Laboratory. One is to understand how genome organization and variation determine individual susceptibility to diseases such as cancer, diabetes, heart disease and neurological diseases. The other is to identify molecular and cellular mechanisms that drive initiation and progression of these diseases. Research on these interconnected themes is based on genetic mouse models. It increasingly involves comparative, ‘in silico' approaches that compare sequences obtained from a next generation genome sequencer with reference genomes. Through these comparative analyses genetic variations such as polymorphisms or copy number variations are determined. Applications such as Burrows-Wheeler, TopHat and Bowtie are used for these analyses that are the basis for further investigations of potential links of these observed anomalies to specific diseases.

To process the large amounts of data generated by the initial genomic sequencing process The Jackson Laboratory currently runs a compute cluster that comprises over 500 cores. Moab HPC Suite guarantees service levels are met while maximizing job throughput. For The Jackson Laboratory the scalable, 'easy-to-use' cluster management solution Scyld ClusterWare and the robust and flexible Moab HPC Suite are key to getting the job throughput required to keep up with the generated sequencing data.

"We chose Scyld and Moab for managing our HPC compute infrastructure as we were looking for a complete HPC solution that works 'out-of-the-box,' takes the complexity out of cluster management and at the same time provides a powerful, scalable scheduling intelligence engine. Our Scyld-Moab cluster supports fine-grained resource control and sophisticated scheduling policies that allow for implementing QoS agreements that are aligned with each group's budgetary contribution to the shared compute resource. We are very happy with Scyld-Moab and it has become a key part of our infrastructure that we plan to extend further going forward," says Glen Beane, Senior Software Engineer at The Jackson Laboratory.

"We are thrilled that we are part of The Jackson Laboratory infrastructure that supports research on life threatening diseases that afflict millions of people. Scyld ClusterWare is the ideal platform for Life Science applications as it is designed for scalability and features a complete HPC stack including a customized pre-configured version of the Moab intelligence engine," says Tom Coull, Vice President and General Manager of Software and Services at Penguin Computing.

"Supporting life-altering research motivates us and we love helping HPC environments achieve their best results. Research work at The Jackson Laboratory makes the world a better place. We are honored to help them intelligently manage and monitor their HPC environment," comments Rob Clyde, CEO of Adaptive Computing.

About Adaptive Computing

Adaptive Computing, manages the world's largest supercomputing environments with its self-optimizing dynamic cloud management solutions and HPC workload management systems driven by Moab, a patented multi-dimensional intelligence engine. Moab delivers policy-based governance, allowing customers to consolidate and virtualize resources, allocate and manage applications, optimize service levels and reduce operational costs. Adaptive Computing is the preferred dynamic cloud and workload management solution for the leading global HPC and datacenter vendors. For more information, call (801) 717-3700 or visit

About Penguin Computing

For well over a decade Penguin Computing has been dedicated to delivering complete, integrated High Performance Computing (HPC) solutions that are innovative, cost effective, and easy to use. Penguin offers a complete end-to-end portfolio of products and solutions ranging from Linux servers and workstations to integrated, turn-key HPC clusters and cluster management software. For those who want to use supercomputing capabilities on-demand and pay as they go, Penguin offers Penguin on Demand (POD), a public HPC cloud that is available instantly and as needed. With its broad portfolio of solutions Penguin is the one-stop shop for HPC and enterprise customers and counts some of the world's most demanding HPC users as its customers, including Caterpillar, Life Technologies, Dolby, Lockheed Martin, the US Air Force, and the US Navy.


Source: Penguin Computing, Inc.

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